- From Sugar Grove, Virginia.
- A legendary luthier and guitarist. Has recorded albums with Doc Watkins, Butch Robins, Steve Kaufman and others.
- As a guitar maker, he has made guitars for Peter Rowan, Gillian Welch, Doc Watson and Eric Clapton.
- 1995, was presented with the Folk Endowment for the Arts award by President Bill Clinton at the White House.
- 1995, the Wayne C. Henderson Music Festival and Guitar Competition was established in his honor in Wilson, Virginia. It takes place on the third Saturday of June every year.
- Sometimes performs as “W.C. Henderson and Co.”
- 2000, toured and recorded with the “Masters of the Steel Stringed Guitar.”
- 2007, performed as part of the “Music from the Crooked Road” tour.
- 2019, was featured in the award-winning documentary film about the Galax Fiddlers Convention titled “Fiddlin.”