- From Mt. Airy, North Carolina; lives in Hendersonville, Tennessee
- Plays all the bluegrass instruments: banjo, guitar, mandolin, fiddle, bass
- 1991, joined Doyle Lawson and Quicksilver
- 1992, joined Alison Krauss and Union Station (took Dan Tyminski’s place for 15 months)
- 1994, married Becky Isaacs and joined the Isaacs
- 2000, released Remember Me album (Mountain Home).
- 2003, released Take This Road album (Mountain Home).
- 2004, left the Isaacs to be a stay-at-home dad for his children. He also taught 4th grade at a local Christian school in LaFollette, Tennessee.
- 2008, joined J.D. Crowe and the New South, playing bass
- 2009, formed The Boxcars with Adam Steffey and Ronnie Stewart.
- 2011, released Family Chain: The Music of Joe Isaacs album (Mountain Home)
- 2014, released Worship Him album (Mountain Home) and left the Boxcars to pursue his calling to the Christian ministry.